Zika virus infection (Zika virus)

Clinical criteria
A person presenting with a rash, with or without fever AND at least one of the following signs and symptoms:
- Arthralgia or
- Myalgia or
- Non-purulent conjunctivitis/hyperaemia

Laboratory criteria
Laboratory criteria for a probable case
Detection of Zika specific IgM antibodies in serum

Laboratory criteria for a confirmed case
At least one of the following:
- Detection of Zika virus nucleic acid in a clinical specimen;
- Detection of Zika virus antigen in a clinical specimen;
- Isolation of Zika virus from a clinical specimen;
- Detection of Zika virus specific IgM antibodies and confirmation using suitably validated flavivirus serological assays;
- Sero-conversion or four-fold increase in the titre of Zika specific antibodies in acute and convalescent serum samples.

Epidemiological criteria
History of exposure in an area with transmission of Zika within two weeks prior to onset of symptoms OR 

Sexual contact with a confirmed case of Zika virus infection in the past eight weeks

Sexual contact with a person who had been in an area with Zika virus transmission in the past eight weeks.

A list of Zika affected areas is kept updated on the HPSC website.

Case classification
A. Possible case
B. Probable case
A person meeting the clinical criteria and the epidemiological criteria. A person meeting the laboratory criteria for a probable case.
C. Confirmed case
A person meeting the laboratory criteria for a confirmed case.

Current as of: 24 January 2019