Acute hepatitis of unknown aetiology case definition

• Confirmed: N/A at present
• Probable: A person presenting with an acute hepatitis (non hepA-E*) with serum transaminase >500 IU/L (AST or ALT), who is 16 years and younger, since 1 October 2021
• Possible: A person presenting with an acute hepatitis (non hepA-E*) with serum transaminase between 200 and 500 IU/L(AST or ALT), and cholestatic who is 16 years and younger, since 1 October 2021
• Epi-linked: A person presenting with an acute hepatitis (non hepA-E*) of any age who is a close contact of a probable case, since 1 October 2021.

*If hepatitis A-E serology results are awaited, but other criteria met, these can be reported and will be classified as “pending classification”. Cases with other explanations for their clinical presentation are discarded.

Last updated: 6 May 2022