HIV post-exposure prophylaxis (PEP) update to Emergency Management of Injury (EMI) Guidelines


The HIV PEP (post-exposure prophylaxis) section of the EMI Guidelines has been updated. The EMI Guidelines are for the emergency management of injuries such as needlesticks, sexual exposure and human bites. The update relates mainly to a recommended new PEP drug regimen for adults that includes Truvada (as previously), but now includes Isentress (Raltegravir) instead of Kaletra. This is now the preferred regimen for adults internationally. Isentress is better tolerated than Kaletra and has fewer drug-drug interactions. It is of proven potency in established HIV infection. The PEP recommendation for children is unchanged.
The EMI Guidelines are available at:

The HIV PEP guidance is available at 
The HIV PEP patient information leaflet has also been revised at: