Lyme disease (Neuroborreliosis) (Borrelia burgdorferi)

Clinical Criteria
— Neurological symptoms according to European Federation of Neurological Societies (EFNS) suggested case definition, without other obvious reasons

Laboratory Criteria
A. Confirmed case
— Pleocytosis in cerebrospinal fluid, AND
— Evidence of intrathecal production of Lyme borreliosis antibodies, OR
— Borrelia burgdorferi sensu lato isolation, OR
— nucleic acid detection in cerebrospinal fluid
OR
— Detection of IgG Lyme borreliosis antibodies in blood specimen only for children (age under 18) with facial palsy or other cranial neuritis and a recent (< 2 months) history of erythema migrans
B. Probable case
— Pleocytosis in cerebrospinal fluid AND positive Lyme borreliosis serology in cerebrospinal fluid
OR
— Specific intrathecal Lyme borreliosis antibody production

Epidemiological Criteria
Not applicable

Case Classification
A. Possible case
Not applicable
B. Probable case
Any person meeting the clinical criteria and at least one of the laboratory criteria for probable cases
C. Confirmed case
- Any person meeting the clinical criteria and at least one of the laboratory criteria for confirmed cases

Current as of: 1 January 2019